Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics
نویسندگان
چکیده
We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ) [1, 2]. FISSEQ-BOINC exhibits different properties from BOINC [3, 4], which relies on bulk nucleic acid sequencing. FISSEQ-BOINC could become a scalable approach for mapping whole-mammalian-brain connectomes with rich molecular annotations.
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